JEDDAH, Saudi Arabia (AP) — U.S. Secretary of State Antony Blinken will travel to Israel this week as part of his sixth urgent mission to the Middle East since the Israelis’ war with Hamas began in October, as relations between the two countries have soured dramatically in recent weeks.

The visit comes amid a flurry of calls and planned visits between U.S. and Israeli officials and public airings of severe disagreements over the state of the conflict.

The State Department said the Israel stop would cap Blinken’s latest Mideast tour that started in Saudi Arabia on Wednesday and will continue in Egypt on Thursday. The top U.S. diplomat will be in Tel Aviv on Friday after talks with Arab leaders and foreign ministers in Jeddah and Cairo focused on the war in Gaza.

“In Israel, Secretary Blinken will discuss with the leadership of the government of Israel the ongoing negotiations to secure the release of all hostages,” State Department spokesman Matthew Miller said. “He will discuss the need to ensure the defeat of Hamas, including in Rafah, in a way that protects the civilian population, does not hinder the delivery of humanitarian assistance, and advances Israel’s overall security.”

Tensions between the U.S. and Israel over the prosecution of the Gaza war have been mounting for months over rising civilian casualties. And they have intensified as Israeli Prime Minister Benjamin Netanyahu has repeatedly said he will ignore President Joe Biden’s warnings not to start a large-scale ground operation in the southern city of Rafah without credible plans to protect innocent Palestinians who have sought refuge there.

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Biden, facing a tough re-election campaign ahead of November’s presidential election, is under growing domestic pressure to rein in Israel’s military response to the Oct. 7 Hamas attacks in Israel.

In a phone call on Monday, their first in more than a month, Netanyahu agreed to send a high-level delegation to Washington to discuss plans, and the Pentagon said Tuesday that Israeli Defense Minister Yoav Gallant would visit the U.S. capital next week.

In his talks in Jeddah, Cairo and Tel Aviv, Blinken is expected to focus on attempts to negotiate a cease-fire and hostage release deal, increase humanitarian aid deliveries to Gaza by land, air and sea and plan for the territory’s post-conflict future.

“We continue to face a horrific humanitarian situation for children, for women, for men in Gaza,” Blinken told reporters at a Tuesday news conference in the Philippines, his stop immediately before Saudi Arabia.

“It is also absolutely incumbent on Israel, as it acts to defend itself and prevent October 7th from happening again, to make it a priority to protect civilians – those who are caught in harm’s way – and to provide for those who desperately need humanitarian assistance,” he said.

In the Red Sea city of Jeddah, Blinken was to meet with Saudi Arabia’s de facto leader, Crown Prince Mohamed bin Salman and the Saudi foreign minister. The prospect of normalization of relations between Saudi Arabia and Israel is seen as a potential point of leverage in pushing the Israelis on easing civilian suffering in Gaza.

But the crown prince has made it clear that normalization won’t happen unless it is accompanied by a clear commitment from Israel to accept an independent Palestinian state by a date certain. Netanyahu and many members of his far-right government are opposed to a Palestinian state.

In Cairo on Thursday, Blinken will see Egyptian officials as well as meet with a six-member Arab committee that includes foreign ministers of Egypt, Saudi Arabia, the United Arab Emirates, Jordan, Morocco and the Palestinian Authority, according to an Egyptian diplomat.

This group has been charged with exploring ways to revamp, reform and revitalize the Palestinian Authority for a possible governance role in Gaza once the war is over. The West Bank-based Palestinian Authority has committed to reforms and replaced some of its top leadership.

Blinken’s discussions are also expected to touch on the cease-fire negotiations that have taken on new urgency as the humanitarian situation in Gaza has become increasingly dire.

Qatari officials, whose country is the main interlocutor with Hamas, said this week they were “cautiously optimistic” after talks with Israel’s intelligence chief in Doha. But, Qatari Foreign Ministry spokesperson Majed al-Ansari said Tuesday that an Israeli ground operation in Rafah would set back any talks.

At least 31,819 Palestinians have been killed, according to Gaza’s Health Ministry, which doesn’t differentiate between civilians and combatants in its count but says women and children make up two-thirds of the dead. A United Nations food agency warned that “famine is imminent” in northern Gaza.

Palestinian militants killed some 1,200 people in the surprise Oct. 7 attack out of Gaza that triggered the war, and and abducted another 250 people. Hamas is still believed to be holding some 100 people hostage, as well as the remains of 30 others.

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